Folate deficiency affects histone methylation
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چکیده
منابع مشابه
Folate deficiency affects histone methylation
Formaldehyde is extremely toxic reacting with proteins to crosslinks peptide chains. Formaldehyde is a metabolic product in many enzymatic reactions and the question of how these enzymes are protected from the formaldehyde that is generated has largely remained unanswered. Early experiments from our laboratory showed that two liver mitochondrial enzymes, dimethylglycine dehydrogenase (DMGDH) an...
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Epidemiological, clinical, and animal studies collectively indicate that dietary folate intake and blood folate levels are inversely associated with colorectal cancer risk. Folate plays an essential role in one-carbon transfer involving remethylation of homocysteine to methionine, which is a precursor of S-adenosylmethionine, the primary methyl group donor for most biological methylations. DNA ...
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DNA methylation has been implicated in chromatin condensation and nuclear organization, especially at sites of constitutive heterochromatin. How this is mediated has not been clear. In this study, using mutant mouse embryonic stem cells completely lacking in DNA methylation, we show that DNA methylation affects nuclear organization and nucleosome structure but not chromatin compaction. In the a...
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I T WAS SHOWN by Toennies et a!.1 that most of the blood folate is within the erythrocytes. The erythrocyte folate level may be reduced in either folate or vitamin B12 deficiency,25 and it can be used as an index of the folate content of body tissues.4 The present paper reports that in iron deficiency anemia there are abnormalities in distribution of folate between plasma and erythrocytes which...
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to the editor: Ramaekers et al. (May 12 issue)1 report 28 patients with the cerebral folate deficiency syndrome characterized by decreased levels of 5-methyltetrahydrofolate (5MTHF) in the cerebrospinal fluid caused by autoantibodies’ blocking of folate transport into the brain. The patients benefited from folinic acid supplementation. The clinical features of this syndrome fit with other neuro...
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ژورنال
عنوان ژورنال: Medical Hypotheses
سال: 2016
ISSN: 0306-9877
DOI: 10.1016/j.mehy.2015.12.027